General symptoms in all affected animal species are blistering (aphthae) in the mouth area, on the udder and on the claws; fever (40-42 °C), pain, apathy, loss of appetite, lameness and a decline in milk yield. Morbidity can reach 100 %. The death rate in adult animals is usually low (up to 5 %), in young calves, lambs and piglets it can be 20 % or more.